In South Africa, Zimbabwe and The Gambia we will establish how frequently two key age-related fractures occur: spine fractures (the commonest) and hip fractures (the most life-challenging). We will assess recovery, disability and death rates following hip fracture, and identify factors that improve outcomes for patients. We will calculate how much fractures cost health services now and in the future.
The menopause is a period of rapid skeletal change which increases fracture risk. Research has seldom focussed on African woman at this stage of life. Understanding mechanisms of bone loss in the context of HIV infection will help inform interventions and guidelines.
This study aims to determine the impact of HIV infection on bone density (BMD) in peri-pubertal children established on ART. 300 HIV-infected children established on ART and 300 HIV-uninfected children aged 8-16 years will be recruited into a frequency-matched prospective cohort study.
This study aims to understand the effect of chronic HIV infection and its treatment on trabecular and cortical bone architecture at different time points through the life course in two independent cohorts from sub-Saharan Africa. The cohort is of children and adolescents followed up for 12 months, and the second of premenopausal women followed up for 24 months.
We will conduct a trial to evaluate the efficacy of high-dose vitamin D3 plus calcium carbonate in improving the musculoskeletal health of children living with HIV infection in sub-Saharan Africa.